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Speech and Deep Brain Stimulation in Parkinson's Disease, Essential Tremor, and Dystonia: A Systematic Review and Meta-analysis
Speech and Deep Brain Stimulation in Parkinson's Disease, Essential Tremor, and Dystonia: A Systematic Review and Meta-analysis
(Wiley-Liss, 2026) Tripoliti E.; Tsuboi T.; Barbe M.T.; Sousa M.; Barkmeier-Kraemer J.; Jergas H.; Arno G.; Buie N.; Day M.; Krýže P.; Nelson J.R.; Warren A.E.L.; Rahimpour S.; Rusz J.; Krack P.; Simonyan K.
Deep brain stimulation (DBS) effectively treats motor symptoms in movement disorders but often compromises speech through incompletely defined mechanisms. We conducted a PROSPERO-registered systematic review and meta-analysis of publications through August 2024 (CRD42024527738). Among 2726 screened records, we included 184 studies: 131 in Parkinson's disease (PD), 32 in essential tremor (ET), and 21 in dystonia, assessing perceptual, acoustic, and patient-reported speech outcomes. Meta-analyses showed that subthalamic nucleus DBS in PD resulted in poorer speech intelligibility compared with best medical treatment (effect size -0.24; 95% confidence interval: -0.46 to -0.03; P = 0.027), with state-dependent decline under active stimulation on longitudinal analysis (Unified Parkinson's Disease Rating Scale Part III item 18 monthly change: medication on +0.016, P < 0.001; medication off +0.002, P = 0.50). In ET, DBS consistently suppressed vocal tremor but increased the risk of dysarthria, particularly with bilateral stimulation. Dystonia outcomes showed greater heterogeneity. Across disorders, sustained phonation measures improved, whereas connected speech performance worsened, indicating selective vulnerability of complex motor tasks. Neuroanatomical mapping identified two nonexclusive mechanisms: current spread to corticobulbar fibers producing spastic speech features and to the cerebellothalamocortical pathway producing ataxic features. Hypokinetic and stuttering-like phenotypes also occurred but likely reflect network-level interactions rather than tract-specific spread. These tract-mediated and network-level alterations appear to interact with hemispheric lateralization, medication state, and longer-term plasticity to produce complex clinical phenotypes. We outline a clinical framework integrating systematic screening, phenotype identification, and targeted programming adjustments. Enhanced speech assessment, precise field mapping, and adaptive DBS paradigms may promote individualized care that optimizes speech and motor function in precision DBS therapy.
QPmR V3: An enhanced implementation of a quasi-polynomial mapping-based root-finder
(Elsevier B.V., 2026) Peichl A.; Vyhlídal T.
Quasi-Polynomial Mapping-Based Root Finder (QPmR) is a widely used algorithm for computing zeros of quasipolynomials arising in the analysis and control of time-delay systems. This paper presents QPmR V3, an enhanced version of the original mapping-based method [1, 2], implemented in MATLAB. The proposed improvements include a region heuristic for retarded and neutral quasi-polynomials based on the spectrum distribution diagram, handling of roots with higher multiplicity, and quadtree-based region subdivision for more efficient root localization. Additional modifications improve numerical robustness and computational efficiency. The MATLAB release of QPmR V3 was developed with emphasis on backward compatibility with previous versions. In addition, a pip-installable open-source Python package is introduced. The proposed methods and implementations are demonstrated on representative benchmark examples, including a comparison with the original QPmR V2 implementation. The results demonstrate improved computational performance and scalability, particularly for large search regions containing many roots, with execution times reduced by up to a factor of 17 compared to QPmR V2.
Design and analysis of spatially symmetric multi-dimensional delayed resonators
(Elsevier Ltd, 2026) Michiels W.; Vyhlídal T.; Kraus K.; Šika Z.
The contribution of the paper is three-fold. First, a novel, spatially symmetric two-dimensional vibration absorber is proposed. Structural conditions are given for unified frequencies and damping ratios, which lead to a one-parameter family of absorbers. Local proportional delayed feedback control laws are then derived that turn the absorber into an ideal absorber with assignable resonance frequency, which generalizes the delayed resonator. Second, it is proven that the time-averaged power requirement of the actuators in operation, deployed to compensate damping and adjust the resonance frequency to the one of a harmonic excitation force, as well as the stability of the controlled absorber, do not depend on the geometry of the unified absorber. However, the power distribution over the links strongly depend on the geometry, as illustrated with a comparison between the new symmetric configuration and a previously proposed asymmetric one. Third, the generalization to spatially symmetric three-dimensional absorbers is addressed. Among other results, it is shown that all admissible spatial configurations for unified frequencies and damping ratios are identical up to reflection and rotation, in sharp contrast to the two-dimensional setting.
Comparsion of Air Transport of Animal Products in Europe and the USA
Srovnání přepravy živočišných produktů leteckou dopravou v Evropě a USA
(Czech Technical University in Prague, 2026-08-04) Kadlec, Jan; Skolilová, Petra; Štěrba, Roman
The bachelors thesis maps logistics processes in Europe and the USA, including legal and technological factors, in connection with the transport of animal products using air transport. The first part of the thesis places the topic within the context of global logistics and mainly serves to provide an introduction to this issue. The second part of the thesis explains the nature of the issue, with a more detailed focus on perishable products in the context of applicable standards, regulations and requirements for their successful transportation. The thesis provides a comprehensive overview of the required documents and based on a comparison with other modes of transport, highlights the key factors that determine the necessity of air transport. It also deals with the comparison of transport of animal products in Europe and the USA in the context of the markets of both regions, as well as with infrastructure, the organization of the logistics chain and the factors influencing transportation. The final part of the thesis presents new trends and technologies used or being developed for the transport of animal products, as well as a practical example from real-world practice demonstrating how a consignment of animal origin is handled at Václav Havel Airport Prague, including the formulation of several recommendations.
Alternative Design of Selected Intersections in the Town Jablonec nad Nisou
Návrh alternativního řešení vybraných křižovatek v Jablonci nad Nisou
(Czech Technical University in Prague, 2026-08-04) Bayer, Ondřej; Čarská, Zuzana; Moudrá, Karolína
Design of the geometric and traffic arrangement of two selected locations comprising three at-grade intersections in Jablonec nad Nisou, with a focus on improving road safety, traffic calming, and enhancing conditions for pedestrians and cyclists. The thesis includes an analysis of the existing conditions and a proposal for the redesign of the section of Dr. Randy Street between its intersections with Riegrova Street and Harrachovská Street.