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Output Driven Optimal Control Design for Time Delay Systems of Neutral Type: A Numerical Case Study
(2026) Fišer J.; Peichl A.; Kuchař M.; Vyhlídal T.
A novel approach to LMI based output driven optimal control design for time delay systems of neutral type is presented. Optimal control synthesis based on a Lyapunov functional proposed reflecting the existence of time delays in both the states and their derivatives constitutes LMI conditions allowing for sensitivity reduction to state time delays variation within the optimization of static output feedback controller. Besides, satisfying LMI conditions appropriately modified the spectral abscissa is estimated and minimized to guarantee acceptable safety in the stability, including the strong stability. Moreover, in case the static output feedback is optimized via the dominant pole placement the assigned poles dominance is checked via these conditions. Numerical burden of solving LMI conditions is relaxed via solving auxiliary iterative LMI problems appropriately parameterized. A numerical case study demonstrates the output driven control design for neutral time delay system and that the auxiliary LMI problem formulation is computationally tractable.
Large language model analysis of real-world phone calls reveals prodromal and progressive biomarker of parkinsonism: A two-year proof-of-concept study
(PUBLIC LIBRARY SCIENCE, 2026) Šubert M.; Illner V.; Novotný M.; Kouba T.; Tykalová T.; Šimek M.; Sovka P.; Švihlík J.; Růžička E.; Šonka K.; Dušek P.; Rusz J.
No sufficiently sensitive biomarker exists to monitor disease progression to assess treatment efficacy in synucleinopathies such as Parkinson's disease (PD), particularly during the prodromal phase when interventions are likely to be most effective. Existing digital biomarkers often rely on active tasks or clinic-based assessments, limiting their scalability and real-world applicability. In this proof-of-concept study, we evaluated whether linguistic features derived from real-world phone call recordings using large language models can serve as a language-based progression biomarker in isolated rapid eye movement sleep behavior (iRBD). In this two-year study, we enrolled 74 participants, including 21 iRBD (20 men), 26 PD (25 men), and 27 healthy controls (26 men) age-matched to iRBD participants. Speech data collection occurred remotely in participants' natural environments through routine phone calls. Over 34,000 phone calls (<1,400 hours) were recorded over the two-year period. Compared to healthy controls, individuals with iRBD exhibited significant declines in sentence coherence (p = 0.016), semantic-syntactic diversity (p < 0.001), topic diversity (p < 0.001), and sentence probability (p < 0.001) over the two years. Prodromal changes in iRBD were detectable with an area under the curve of 0.82 from as few as 21 calls. For a two-year neuroprotective trial targeting 50% drug efficacy, the estimated sample size was 78 iRBD participants per arm based on a time-to-event analysis. These findings demonstrate that fully automated phone call analysis can detect both prodromal and progressive changes in alpha-synucleinopathy. This approach is scalable, minimizes the effort required from both patients and clinical staff, and enables remote, low-burden monitoring in screening at-risk populations and therapeutic trials.
Simulations and Measurement of Temperatures in Bridge Structures Vít Němčic1,a*, Jan L. Vítek2,b and Jiří Lukeš3,c and Measurement of Temperatures in Bridge Structures
(Trans Tech Publications, 2026) Němčic V.; Vítek J.; Lukeš J.
Massive structures are exposed to the risk of high temperatures due to cement hydration. With the requirement for sustainable development, the clinker content of conventionally manufactured cements is being reduced, resulting in the development of blended cements, which are gradually being introduced into production. Therefore, the development of temperatures in massive concrete structures containing modern blended cement is the subject of an experimental program. Its results are evaluated not only in terms of the properties of the resulting concrete, but also in terms of the possibility of concrete production and the technology of mixing. Finally, recommendations are given for the design of concrete mixtures for massive structures. Furthermore, the article deals with the comparison of the measured values with the thermal analysis of the structures.
Research of Quality Aspects of Simulation for the Development of Interactive Motorcycle Simulators
Výzkum aspektů kvality simulace pro vývoj interaktivních simulátorů motocyklů
(Czech Technical University in Prague) Svoboda, Josef; Novotný, Stanislav; Mouček, Roman; Hrubeš, Pavel
The dissertation addresses the issue of motorcycle riding simulation quality in interactive simulation environments. The main objective of the work is to identify, analyse, and experimentally verify the aspects that significantly influence simulation quality and fidelity from the rider´s perspective, and to propose approaches for their transfer into interactive simulation environments. For this purpose, an original interactive motorcycle simulator was iteratively designed and implemented. The simulator includes a physical model implemented within a virtual environment, hardware components including a rider input sensing system, a visualization system, and a feedback system based primarily on a Gough-Stewart motion platform. During the development process, a series of partial experiments was conducted to verify individual subsystems, including the validation of the mathematical-physical model of the virtual motorcycle based on a comparison with riding dynamics data measured under real conditions. Within the scope of the work, key aspects of simulation quality and the conditions for their mutual integration were identified. The main contribution of the dissertation lies in their experimental verification and application in the design and implementation of a functional prototype of a motorcycle simulator. The results of the work have potential applications in the development of HMI systems and rider training in a safe and controlled environment.
City library, Žižkov
Městská knihovna, Žižkov
(Czech Technical University in Prague, 2026-05-25) Herasymova, Diana; Ribeiro Marques, Luis Miguel; Krátký, Vladimír; Pfeifer, Josef
The subject of the bachelor thesis is the design of a new municipal library in Prague 3 Žižkov. The building is designed as a public civic amenity structure focused on creating an open community space combining the functions of a library, study rooms, café, and public ground floor areas. The urban concept responds to the corner plot and the surrounding block development. The building consists of one underground and four above-ground floors. The structural system is designed as a monolithic reinforced concrete frame combined with a wall system. The façade is formed by a ventilated cladding system with large-format fibre cement panels. The project also includes a green roof, accessible terrace, and barrier-free design throughout the building. The technical design includes an air-to-water heat pump, mechanical ventilation with heat recovery, and a rainwater management system using a retention tank. The proposal respects current requirements for fire safety, energy performance, hygiene, and technical regulations.