Vývoj vlákenných materiálů pro regeneraci vazivové/kostní tkáně metodou MEW

Abstract

Anterior Cruciate ligament (ACL) injury is a common soft tissue injury. The ACL plays an essential role in the stability of the knee joint and, due to its poor vascularity, has limited healing capacity. Current ACL injury treatments have several disadvantages, including osteoarthritis and ligament rupture, leading to the need of tissue engineered (TE) solutions to ACL injury. Melt Electrospinning Writing (MEW) is a recently developed technology which allows for the fabrication of controlled fibrous architectures reminiscent of the native extracellular matrix (ECM) of ligament and bone tissues. Printing methods for a suitable scaffold for bone TE has been established, and ligament scaffolds have been explored in the Hoey lab. This study aims to further explore the development of a suitable scaffold for ligament tissue engineering, and to develop a biphasic MEW printed scaffold which includes a bone and a ligament region.

Anterior Cruciate ligament (ACL) injury is a common soft tissue injury. The ACL plays an essential role in the stability of the knee joint and, due to its poor vascularity, has limited healing capacity. Current ACL injury treatments have several disadvantages, including osteoarthritis and ligament rupture, leading to the need of tissue engineered (TE) solutions to ACL injury. Melt Electrospinning Writing (MEW) is a recently developed technology which allows for the fabrication of controlled fibrous architectures reminiscent of the native extracellular matrix (ECM) of ligament and bone tissues. Printing methods for a suitable scaffold for bone TE has been established, and ligament scaffolds have been explored in the Hoey lab. This study aims to further explore the development of a suitable scaffold for ligament tissue engineering, and to develop a biphasic MEW printed scaffold which includes a bone and a ligament region.