Vývoj vlákenných materiálů pro regeneraci vazivové/kostní tkáně metodou MEW

Development of Melt Electro written fibrous materials for ligament/bone tissue regeneration

Typ dokumentu
diplomová práce
master thesis
Autor
Daan Wolters
Vedoucí práce
Ráfl Jakub
Oponent práce
Otáhal Martin
Studijní program
Biomedicínské a klinické inženýrství
Instituce přidělující hodnost
katedra biomedicínské techniky


Práva
A university thesis is a work protected by the Copyright Act. Extracts, copies and transcripts of the thesis are allowed for personal use only and at one?s own expense. The use of thesis should be in compliance with the Copyright Act http://www.mkcr.cz/assets/autorske-pravo/01-3982006.pdf and the citation ethics http://knihovny.cvut.cz/vychova/vskp.html
Vysokoškolská závěrečná práce je dílo chráněné autorským zákonem. Je možné pořizovat z něj na své náklady a pro svoji osobní potřebu výpisy, opisy a rozmnoženiny. Jeho využití musí být v souladu s autorským zákonem http://www.mkcr.cz/assets/autorske-pravo/01-3982006.pdf a citační etikou http://knihovny.cvut.cz/vychova/vskp.html
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Abstrakt
Anterior Cruciate ligament (ACL) injury is a common soft tissue injury. The ACL plays an essential role in the stability of the knee joint and, due to its poor vascularity, has limited healing capacity. Current ACL injury treatments have several disadvantages, including osteoarthritis and ligament rupture, leading to the need of tissue engineered (TE) solutions to ACL injury. Melt Electrospinning Writing (MEW) is a recently developed technology which allows for the fabrication of controlled fibrous architectures reminiscent of the native extracellular matrix (ECM) of ligament and bone tissues. Printing methods for a suitable scaffold for bone TE has been established, and ligament scaffolds have been explored in the Hoey lab. This study aims to further explore the development of a suitable scaffold for ligament tissue engineering, and to develop a biphasic MEW printed scaffold which includes a bone and a ligament region.
 
Anterior Cruciate ligament (ACL) injury is a common soft tissue injury. The ACL plays an essential role in the stability of the knee joint and, due to its poor vascularity, has limited healing capacity. Current ACL injury treatments have several disadvantages, including osteoarthritis and ligament rupture, leading to the need of tissue engineered (TE) solutions to ACL injury. Melt Electrospinning Writing (MEW) is a recently developed technology which allows for the fabrication of controlled fibrous architectures reminiscent of the native extracellular matrix (ECM) of ligament and bone tissues. Printing methods for a suitable scaffold for bone TE has been established, and ligament scaffolds have been explored in the Hoey lab. This study aims to further explore the development of a suitable scaffold for ligament tissue engineering, and to develop a biphasic MEW printed scaffold which includes a bone and a ligament region.
 
URI
http://hdl.handle.net/10467/104572
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