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Nitrogen soft X-ray source for imaging of biological objects



dc.contributor.advisorVrbová Miroslava
dc.contributor.authorŠárka Salačová
dc.date.accessioned2020-09-30T11:19:10Z
dc.date.available2020-09-30T11:19:10Z
dc.date.issued2020-09-10
dc.identifierKOS-331516680205
dc.identifier.urihttp://hdl.handle.net/10467/90935
dc.description.abstractSoft X-ray radiation sources usable for microscopy have been studied in the laboratory XUV at CTU Faculty of Biomedical Engineering. This thesis is focused on the optimization of generation quasi-monochromatic radiation with a water window wavelength of 2.88 nm. The source of radiation is a laser plasma created in Nitrogen gas-pu target. The optimization function is delineated in chapter 1.5.1. Gradually, the eect of system parameters on the output energy is investigated. For the microscopic imaging, we need high energy in a single shot at the output of the SXR source. The biggest eect on the output of pulse energy has a mass density spatial distribution in the gas-pu target. We studied it via laboratory experiments and computer modelling. In chapter 4.1, we supply information about the eect of nozzle ageing and investigation of double stream nozzle. We used Z star code to construct a complete model of the gas-pu target. In chapter 4.2, the results of computer modelling are compared with experimental data. This comparison is very important as the Z star code (developed for plasma magnetohydrodynamics) has not yet been used for gas ow simulations. Plasma radiation, modelled by the Z-star code, is given in chapter 5. The computer model of the source may be further used for the design of improved SXR source. We paid attention also to biological samples and after a literature search, we present results of SXR microscopy image of CT 26 broblasts, derived from colon carcinoma Mus musculus (strain BALB/c) in chapter 6.cze
dc.description.abstractSoft X-ray radiation sources usable for microscopy have been studied in the laboratory XUV at CTU Faculty of Biomedical Engineering. This thesis is focused on the optimization of generation quasi-monochromatic radiation with a water window wavelength of 2.88 nm. The source of radiation is a laser plasma created in Nitrogen gas-pu target. The optimization function is delineated in chapter 1.5.1. Gradually, the eect of system parameters on the output energy is investigated. For the microscopic imaging, we need high energy in a single shot at the output of the SXR source. The biggest eect on the output of pulse energy has a mass density spatial distribution in the gas-pu target. We studied it via laboratory experiments and computer modelling. In chapter 4.1, we supply information about the eect of nozzle ageing and investigation of double stream nozzle. We used Z star code to construct a complete model of the gas-pu target. In chapter 4.2, the results of computer modelling are compared with experimental data. This comparison is very important as the Z star code (developed for plasma magnetohydrodynamics) has not yet been used for gas ow simulations. Plasma radiation, modelled by the Z-star code, is given in chapter 5. The computer model of the source may be further used for the design of improved SXR source. We paid attention also to biological samples and after a literature search, we present results of SXR microscopy image of CT 26 broblasts, derived from colon carcinoma Mus musculus (strain BALB/c) in chapter 6.eng
dc.publisherČeské vysoké učení technické v Praze. Vypočetní a informační centrum.cze
dc.publisherCzech Technical University in Prague. Computing and Information Centre.eng
dc.rightsA university thesis is a work protected by the Copyright Act. Extracts, copies and transcripts of the thesis are allowed for personal use only and at one?s own expense. The use of thesis should be in compliance with the Copyright Act http://www.mkcr.cz/assets/autorske-pravo/01-3982006.pdf and the citation ethics http://knihovny.cvut.cz/vychova/vskp.htmleng
dc.rightsVysokoškolská závěrečná práce je dílo chráněné autorským zákonem. Je možné pořizovat z něj na své náklady a pro svoji osobní potřebu výpisy, opisy a rozmnoženiny. Jeho využití musí být v souladu s autorským zákonem http://www.mkcr.cz/assets/autorske-pravo/01-3982006.pdf a citační etikou http://knihovny.cvut.cz/vychova/vskp.htmlcze
dc.subjectsoft x-ray radiationcze
dc.subjectlaser-produced plasma sourcecze
dc.subjectgas-pu targetcze
dc.subjectCTcze
dc.subjectsoft x-ray radiationeng
dc.subjectlaser-produced plasma sourceeng
dc.subjectgas-pu targeteng
dc.subjectCTeng
dc.titleNitrogen soft X-ray source for imaging of biological objectscze
dc.titleNitrogen soft X-ray source for imaging of biological objectseng
dc.typedisertační prácecze
dc.typedoctoral thesiseng
dc.contributor.refereePína Ladislav
theses.degree.disciplineBiomedicínská a klinická technikacze
theses.degree.grantorkatedra přírodovědných oborůcze
theses.degree.programmeBiomedicínská a klinická technika (4)cze


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