Vytvoření nástroje pro zpracování dat z RNAseq analýz pacientů s leukemickým onemocněním
A tool for RNAseq data processing in patients with leukemia
| dc.contributor.advisor | Klempíř Ondřej | |
| dc.contributor.author | Michaela Součková | |
| dc.date.accessioned | 2023-11-06T09:01:42Z | |
| dc.date.available | 2023-11-06T09:01:42Z | |
| dc.date.issued | 2023-06-21 | |
| dc.identifier | KOS-1240996784105 | |
| dc.identifier.uri | http://hdl.handle.net/10467/112592 | |
| dc.description.abstract | The aim is to develop a bioinformatic Nextflow pipeline that would analyse RNAseq data of leukemic patients with the emphasis on fusion gene detection. Since gene fusions are believed to be associated with tumour phenotype, they have been of significant importance for clinical purposes, as well as for understanding tumorigenesis. With mapping current trends in RNAseq data processing and fusion detection, we provide a modular workflow consisting of processes that leverage suitable bioinformatic tools and manage fusion gene detection along with pre-processing and validation. The detected fusion candidates are preprepared as a formatted summary table for subsequent expert analysis. | cze |
| dc.description.abstract | The aim is to develop a bioinformatic Nextflow pipeline that would analyse RNAseq data of leukemic patients with the emphasis on fusion gene detection. Since gene fusions are believed to be associated with tumour phenotype, they have been of significant importance for clinical purposes, as well as for understanding tumorigenesis. With mapping current trends in RNAseq data processing and fusion detection, we provide a modular workflow consisting of processes that leverage suitable bioinformatic tools and manage fusion gene detection along with pre-processing and validation. The detected fusion candidates are preprepared as a formatted summary table for subsequent expert analysis. | eng |
| dc.publisher | České vysoké učení technické v Praze. Vypočetní a informační centrum. | cze |
| dc.publisher | Czech Technical University in Prague. Computing and Information Centre. | eng |
| dc.rights | A university thesis is a work protected by the Copyright Act. Extracts, copies and transcripts of the thesis are allowed for personal use only and at one?s own expense. The use of thesis should be in compliance with the Copyright Act http://www.mkcr.cz/assets/autorske-pravo/01-3982006.pdf and the citation ethics http://knihovny.cvut.cz/vychova/vskp.html | eng |
| dc.rights | Vysokoškolská závěrečná práce je dílo chráněné autorským zákonem. Je možné pořizovat z něj na své náklady a pro svoji osobní potřebu výpisy, opisy a rozmnoženiny. Jeho využití musí být v souladu s autorským zákonem http://www.mkcr.cz/assets/autorske-pravo/01-3982006.pdf a citační etikou http://knihovny.cvut.cz/vychova/vskp.html | cze |
| dc.subject | RNAseq | cze |
| dc.subject | fusion gene | cze |
| dc.subject | Nextflow | cze |
| dc.subject | RNAseq | eng |
| dc.subject | fusion gene | eng |
| dc.subject | Nextflow | eng |
| dc.title | Vytvoření nástroje pro zpracování dat z RNAseq analýz pacientů s leukemickým onemocněním | cze |
| dc.title | A tool for RNAseq data processing in patients with leukemia | eng |
| dc.type | diplomová práce | cze |
| dc.type | master thesis | eng |
| dc.date.accepted | 2023-06-21 | |
| dc.contributor.referee | Kazantsev Dmitry | |
| theses.degree.discipline | Softwarové technologie | cze |
| theses.degree.grantor | katedra biomedicínské informatiky | cze |
| theses.degree.programme | Biomedicínská a klinická informatika | cze |