• Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensor AfGcHK abolishes bacterial signal transduction 

      Autor: Skalova T.; Lengalova Al.; Dohnalek J.; Harlos K.; Mihalcin P.; Kolenko P.; Stranava M.; Blaha J.; Shimizu T.; Martínková M.
      (American Society for Biochemistry and Molecular Biology, Inc., 2020)
      The heme-based oxygen sensor protein AfGcHK is a globin- coupled histidine kinase in the soil bacterium Anaeromyxobac- ter sp. Fw109-5. Its C-terminal functional domain exhibits autophosphorylation activity induced by ...
    • Flexible regions govern promiscuous binding of IL-24 to receptors IL-20R1 and IL-22R1 

      Autor: Zahradník J.; Kolářová L.; Peleg Y.; Kolenko P.; Svidenská S.; Charnavets T.; Unger T.; Sussman J.L.; Schneider B.
      (John Wiley & Sons, 2019)
      Interleukin 24 (IL-24) is a cytokine with the potential to be an effective treatment for autoimmune diseases and cancer. However, its instability and difficulties in its production have hampered detailed biological and ...
    • Paired refinement under the control of PAIREF 

      Autor: Malý M.; Diederichs K.; Dohnalek J.; Kolenko P.
      (International Union of Crystallography, 2020)
      Crystallographic resolution is a key characteristic of diffraction data and represents one of the first decisions an experimenter has to make in data evaluation. Conservative approaches to the high-resolution cutoff ...
    • Structural basis of prostate-specific membrane antigen recognition by the A9g RNA aptamer 

      Autor: Ptacek J.; Zhang D.; Qiu L.; Kruspe S.; Motlova L.; Kolenko P.; Novakova Z.; Shubham S.; Havlinova B.; Baranova P.; Chen S.-J.; Zou X.; Giangrande P.; Barinka C.
      (Oxford University Press, 2020)
      Prostate-specific membrane antigen (PSMA) is a well-characterized tumor marker associated with prostate cancer and neovasculature of most solid tumors. PSMA-specific ligands are thus being developed to deliver imaging or ...
    • Úvod do fyziky pevných látek 

      Autor: Kolenko P.
      (Czech Technical University in Prague, 2023)