External validation of extended prostate biopsy nomogram
Type of document
článek v časopisejournal article
Peer-reviewed
submittedVersion
Author
Hrbáček J.
Minárik I.
Sieger T.
Babjuk M.
Rights
openAccessMetadata
Show full item recordAbstract
Introduction
Historical nomograms for the prediction of cancer on prostate biopsy, developed in the sex-
tant biopsy era are no more accurate today. The aim of this study was an independent external validation
of a 10-core biopsy nomogram by Chun et al. (2007).
Material and methods
A total of 322 patients who presented for their initial biopsy in a tertiary care
center and had all the necessary data available were included in the retrospective analysis. To validate
the nomogram, receiver operator characteristic (ROC) curves and calibration plots were constructed.
Results
Area under the ROC curve calculated for our data using the nomogram was 0.773, similar to that
reported originally. However, the nomogram systematically overestimated prostate cancer risk, which,
for our data, could be resolved by subtracting 24 points from the total number of points of the nomogram.
Conclusions
The nomogram yielded overall good predictive accuracy as measured by the area under the
ROC curve, but it systematically overestimated PC probability in individual patients. However, we showed
how the nomogram could easily be adapted to our patient sample, resolving the bias issue.
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