Prediction of DNA-binding propensity of proteins by the ball-histogram method using automatic template search
Typ dokumentu
článek z elektronického periodikaAutor
Szabóová, Andrea
Kuželka, Ondřej
Železný, Filip
Tolar, Jakub
Práva
open accessMetadata
Zobrazit celý záznamAbstrakt
We contribute a novel, ball-histogram approach to DNA-binding propensity prediction of proteins. Unlike state-ofthe-
art methods based on constructing an ad-hoc set of features describing physicochemical properties of the
proteins, the ball-histogram technique enables a systematic, Monte-Carlo exploration of the spatial distribution of
amino acids complying with automatically selected properties. This exploration yields a model for the prediction of
DNA binding propensity. We validate our method in prediction experiments, improving on state-of-the-art
accuracies. Moreover, our method also provides interpretable features involving spatial distributions of selected
amino acids.
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