Impaired dual-task gait in Parkinson’s disease is associated with brain morphology changes
dc.contributor.author | Krupička R. | |
dc.contributor.author | Malá C. | |
dc.contributor.author | Neťuková S. | |
dc.contributor.author | Hubená T. | |
dc.contributor.author | Havlík F. | |
dc.contributor.author | Bezdicek O. | |
dc.contributor.author | Dušek P. | |
dc.contributor.author | Ružička E. | |
dc.date.accessioned | 2024-03-01T14:24:33Z | |
dc.date.available | 2024-03-01T14:24:33Z | |
dc.date.issued | 2024 | |
dc.identifier | V3S-372869 | |
dc.identifier.citation | KRUPIČKA, R., et al. Impaired dual-task gait in Parkinson’s disease is associated with brain morphology changes. Journal of Neural Transmission. 2024, 1-7. ISSN 0300-9564. DOI 10.1007/s00702-024-02758-2. | |
dc.identifier.issn | 0300-9564 (print) | |
dc.identifier.issn | 1435-1463 (online) | |
dc.identifier.uri | http://hdl.handle.net/10467/113993 | |
dc.description.abstract | In Parkinson’s disease (PD), impaired gait and cognition affect daily activities, particularly in the more advanced stages of the disease. This study investigated the relationship between gait parameters, cognitive performance, and brain morphology in patients with early untreated PD. 64 drug-naive PD patients and 47 healthy controls (HC) participated in the study. Single- and dual-task gait (counting task) were examined using an expanded Timed Up & Go Test measured on a GaitRite walkway. Measurements included gait speed, stride length, and cadence. A brain morphometry analysis was performed on T1-weighted magnetic resonance (MR) images. In PD patients compared to HC, gait analysis revealed reduced speed (p < 0.001) and stride length (p < 0.001) in single-task gait, as well as greater dual-task cost (DTC) for speed (p = 0.007), stride length (p = 0.014) and cadence (p = 0.029). Based on the DTC measures in HC, PD patients were further divided into two subgroups with normal DTC (PD-nDTC) and abnormally increased DTC (PD-iDTC). For PD-nDTC, voxel-based morphometric correlation analysis revealed a positive correlation between a cluster in the left primary motor cortex and stride-length DTC (r = 0.57, p = 0.027). For PD-iDTC, a negative correlation was found between a cluster in the right lingual gyrus and the DTC for gait cadence (r=-0.35, pFWE = 0.018). No significant correlations were found in HC. The associations found between brain morphometry and gait performance with a concurrent cognitive task may represent the substrate for gait and cognitive impairment occurring since the early stages of PD. | eng |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartof | Journal of Neural Transmission | |
dc.rights | Creative Commons Attribution (CC BY) 4.0 | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Dual-task cost | eng |
dc.subject | Gait speed | eng |
dc.subject | Stride length | eng |
dc.subject | Stepping cadence | eng |
dc.subject | Timed up and go test | eng |
dc.subject | Morphometric correlation analysis | eng |
dc.title | Impaired dual-task gait in Parkinson’s disease is associated with brain morphology changes | eng |
dc.type | článek v časopise | cze |
dc.type | journal article | eng |
dc.identifier.doi | 10.1007/s00702-024-02758-2 | |
dc.relation.projectid | info:eu-repo/grantAgreement/Ministry of Health/NU/NU20-04-00327/CZ/Disorders of gait, postural stability and cognition in Parkinson's disease: presymptomatic detection and targeted rehabilitation/ | |
dc.relation.projectid | info:eu-repo/grantAgreement/Ministry of Education, Youth and Sports/LX/LX22NPO5107/CZ/National institute for Neurological Research/NPO-NEURO-D | |
dc.rights.access | openAccess | |
dc.type.status | Peer-reviewed | |
dc.type.version | acceptedVersion |
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Kromě případů, kde je uvedeno jinak, licence tohoto záznamu je Creative Commons Attribution (CC BY) 4.0