Collagen in bone tissue regeneration: Focusing on the mechanical and structural constraints
Type of documenthabilitační práce
Institutions assigning rankČeské vysoké učení technické v Praze. Fakulta strojní
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This study demonstrates the effect of various processing conditions on the mechanical, structural and utility characteristics of collagen materials to be used for bone tissue regeneration purposes in both the microstructured and nanostructured forms. The first part presents the effective cross-linking conditions and composition of collagen microstructured composites, focusing on the collagen content and their final characteristics such as mechanical properties, internal structure and porosity in both the dry and hydrated states. The second part presents an assessment of the effective processing and cross-linking conditions of nanostructured electrospun collagen with respect to its mechanical and structural properties and the preservation of the native structure of the collagen. The third part presents the development of a biodegradable nanostructured electrospun composite layer for the treatment of implant-associated infections and improvements with respect to the rate of osseointegration.
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