Registration of multiple stained histological sections
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ArticleAuthor
Borovec, Jiří
Kybic, Jan
Bušta, Michal
Ortiz-de-Solórzano, Carlos
Muñoz-Barrutia, Arrate
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(c) 2013 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other worksMetadata
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The analysis of protein-level multigene expression signature maps computed from the fusion of differently stained immunohistochemistry images is an emerging tool in cancer management. Creating these maps requires registering sets of histological images, a challenging task due to their large size, the non-linear distortions existing between consecutive sections and to the fact that the images correspond to different histological stains and thus, may have very different appearance. In this manuscript, we present a novel segmentation-based registration algorithm that exploits a multi-class pyramid and optimizes a fuzzy class assignment specially designed for this task. Compared to a standard nonrigid registration, the proposed method achieves an improved matching on both synthetic as well as real histological images of cancer lesions.
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