Biomechanická studie Syringomyelie s Chiariho malformací - mechanika míchy
A computational biomechanics study of the Chiari-Syringomyelia complex - Mechanics of Spinal Cord
Typ dokumentu
diplomová prácemaster thesis
Autor
Asawari Pratiksha Ashok Kumbhar
Vedoucí práce
Rožánek Martin
Oponent práce
Maršálek Petr
Studijní obor
Biomedicínské inženýrstvíStudijní program
Biomedicínská a klinická technika (studium v angličtině)Instituce přidělující hodnost
katedra biomedicínské technikyPráva
A university thesis is a work protected by the Copyright Act. Extracts, copies and transcripts of the thesis are allowed for personal use only and at one?s own expense. The use of thesis should be in compliance with the Copyright Act http://www.mkcr.cz/assets/autorske-pravo/01-3982006.pdf and the citation ethics http://knihovny.cvut.cz/vychova/vskp.htmlVysokoškolská závěrečná práce je dílo chráněné autorským zákonem. Je možné pořizovat z něj na své náklady a pro svoji osobní potřebu výpisy, opisy a rozmnoženiny. Jeho využití musí být v souladu s autorským zákonem http://www.mkcr.cz/assets/autorske-pravo/01-3982006.pdf a citační etikou http://knihovny.cvut.cz/vychova/vskp.html
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The pathogenesis of syringomyelia in association with Chiari malformation (CM) is unclear. The mechanical properties of solid tissues and cerebrospinal fluid flow have been shown to contribute to the development of syrinx. This thesis aims to study the biomechanical behavior of the spinal cord in the aforementioned diseased condition. A 2D axisymmetric poroelastic model of the spinal cord in the presence of syringomyelia was developed to understand the flow dynamics in porous solids. An arterial pressure pulse of 500 Pa was applied at the cranial end of the subarachnoid space. Transient excitation gave rise to wave propagation in the fluid-filled subarachnoid space. The main effect of the excitation was compression and swelling of spinal cord tissue at the syrinx level at different pressure conditions. The velocities of fluid entering and leaving the syrinx were relatively low i.e., in the range of 10-5 m/s such that the porous spinal cord absorbing the fluid. Stresses induced in pia mater were larger at the level of syrinx as compared to the rest of the model geometry. Although poroelasticity gives a major insight into the material interaction with fluid in a porous media, it lacks the complexities involved in free flow equations which are more realistic to determine the behavior of biological tissue. An extension to the existing model with the fluid-structure interaction module was built to study the effect of the free-flow zone connected to the poroelastic media. The pathogenesis of syringomyelia in association with Chiari malformation (CM) is unclear. The mechanical properties of solid tissues and cerebrospinal fluid flow have been shown to contribute to the development of syrinx. This thesis aims to study the biomechanical behavior of the spinal cord in the aforementioned diseased condition. A 2D axisymmetric poroelastic model of the spinal cord in the presence of syringomyelia was developed to understand the flow dynamics in porous solids. An arterial pressure pulse of 500 Pa was applied at the cranial end of the subarachnoid space. Transient excitation gave rise to wave propagation in the fluid-filled subarachnoid space. The main effect of the excitation was compression and swelling of spinal cord tissue at the syrinx level at different pressure conditions. The velocities of fluid entering and leaving the syrinx were relatively low i.e., in the range of 10-5 m/s such that the porous spinal cord absorbing the fluid. Stresses induced in pia mater were larger at the level of syrinx as compared to the rest of the model geometry. Although poroelasticity gives a major insight into the material interaction with fluid in a porous media, it lacks the complexities involved in free flow equations which are more realistic to determine the behavior of biological tissue. An extension to the existing model with the fluid-structure interaction module was built to study the effect of the free-flow zone connected to the poroelastic media.
Kolekce
- Diplomové práce - 17110 [1011]