Korelační analýza morfologie mozku s parametry DATScan a skóre UPDRS III u pacientů s iRBD a Parkinsonovou chorobou

Abstract

Parkinsons Disease (PD) is a neurodegenerative disease, affecting 23% of the population over 65 years, with a pandemic-like pattern of increasing prevalence. REM Sleep Behaviour Disorder (RBD) is a sleeping disorder characterized by sleep-enacting behaviours, harmful to the affected or their sleeping partner. Idiopathic RBD is considered a prelude to α-synucleinopathies, such as PD. The project aims to investigate possible correlations between brain morphology and DaTScan and UPDRS-III results in three patient groups: PD, iRBD and healthy controls. All analyses were performed in SPM and CAT12, on the cerebrum and extended to the cerebellum. Voxel-Based Morphometry (VBM) found positive correlation with putamen DaTScan results in PD patients in the left middle frontal gyrus (pFWE=0.01) and the right middle cingulum (pFWE=0.004). A negative correlation in grey matter density and UPDRS-III scores were observed in lobe VI of the left cerebellum (pFWE=0.032). Region-of-Interest analysis found statistically significant correlations (p<0.05, Holm-Bonferroni corrected) between structures in the frontal, parietal, and temporal lobes, for both marker parameters in PD patients, as well as the cingulate gyrus for DaTScan. Furthermore, statistically significant correlation was found between lobe X of the left cerebellum and UPDRS-III scores of iRBD patients (p<0.05, Holm-Bonferroni corrected). These results confirm both UPDRS-IIIs and DaTScans efficacy as measures of disease progression, drawing parallels with morphological changes in the brain.Parkinsons Disease (PD) is a neurodegenerative disease, affecting 23% of the population over 65 years, with a pandemic-like pattern of increasing prevalence. REM Sleep Behaviour Disorder (RBD) is a sleeping disorder characterized by sleep-enacting behaviours, harmful to the affected or their sleeping partner. Idiopathic RBD is considered a prelude to α-synucleinopathies, such as PD. The project aims to investigate possible correlations between brain morphology and DaTScan and UPDRS-III results in three patient groups: PD, iRBD and healthy controls. All analyses were performed in SPM and CAT12, on the cerebrum and extended to the cerebellum. Voxel-Based Morphometry (VBM) found positive correlation with putamen DaTScan results in PD patients in the left middle frontal gyrus (pFWE=0.01) and the right middle cingulum (pFWE=0.004). A negative correlation in grey matter density and UPDRS-III scores were observed in lobe VI of the left cerebellum (pFWE=0.032). Region-of-Interest analysis found statistically significant correlations (p<0.05, Holm-Bonferroni corrected) between structures in the frontal, parietal, and temporal lobes, for both marker parameters in PD patients, as well as the cingulate gyrus for DaTScan. Furthermore, statistically significant correlation was found between lobe X of the left cerebellum and UPDRS-III scores of iRBD patients (p<0.05, Holm-Bonferroni corrected). These results confirm both UPDRS-IIIs and DaTScans efficacy as measures of disease progression, drawing parallels with morphological changes in the brain.